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Product Overview
Other ingredients: Dicalcium phosphate, microcrystalline cellulose, croscarmellose sodium, stearic acid, magnesium stearate, silica and pharmaceutical glaze.
More about the Key Ingredients Glucosamine Sulfate - 1500mg The body naturally uses glucosamine sulfate in the production of glycosaminoglycans, which are major components of the joint cartilage matrix and the synovial fluid that lubricates the joints. Studies have shown that glucosamine sulfate promotes joint comfort, flexibility and range of motion, while it also helps maintain the structural integrity of the joints.i Boswellia serrata resin extract - 250mg The medicinal use of boswellia dates back to the ancient Egyptians, and it remains an important ingredient in foods, beverages and cosmetics to this day. Boswellic acids extracted from the resin of the Boswellia serrata tree have been shown to inhibit some of the enzymes responsible for inflammation. Unlike some common anti-inflammatory medicines, boswellia extracts have not shown adverse gastrointestinal effects in studies.ii Resveratrol/Japanese knotweed root extract - 50mg Resveratrol is a member of the family of plant-based nutrients called phytoalexins, a name that is derived from the Greek words for "plant" and "protectors." Resveratrol was originally isolated from the ancient Asian medicinal plant, Polygonum cuspidatum, or Japanese knotweed root. It has since been discovered in grape plants, and in 1991, in red wine. Because of the red wine connection, much of the excitement over resveratrol has focused on its potential to promote a healthy cardiovascular system through its strong antioxidant and vaso-protective activities. Laboratory studies have also shown that resveratrol can have a positive influence on some of the enzymes responsible for inflammation, including cycloogygenase and lipoxygenase. The trans isomer of resveratrol is considered to be the most biologically active. iii Comfort Support Proprietary Blend - 750mg Bromelain Bromelain is the common name used to describe a water-based extract of pineapples that has been standardized to a specific level of proteolytic (protein-digesting) activity, such as GDUs (or Gelatin Dissolving Units). A recent review of some of the major scientific investigations of bromelain suggests that it can play an important role in promoting joint comfort.iv Feverfew The leaves of the feverfew (Tanacetum parthenium) have been used medicinally for centuries. While experts suggest that more research is needed to firmly establish its efficacy, studies have documented feverfew's ability to limit the production of pro-inflammatory prostaglandins.v Hops While hops are most famous for their role in the brewing of beer, the recent scientific attention paid to hops has nothing to do with the crafting of a new lager. Hops contain anti-inflammatory compounds known as alpha acids that have been shown to improve joint comfort and mobility in a pilot clinical trial.vi White Willow Bark White willow bark contains salicin, a close chemical cousin of aspirin. In fact, aspirin, or acetylsalicylic acid, was originally produced using the salicin in white willow bark. Studies have confirmed that many of aspirin's benefits can also be achieved with white willow extracts.vii Sea Cucumber Even though the name makes them sound like a form of oceanic vegetable, sea cucumbers are actually echinoderms and are related to starfish and sea urchins. They are considered a dietary delicacy in many Asian countries where they are also used for medicinal reasons. Sea cucumbers are a rich source of glycosaminoglycans, including chondroitin sulfate, which explains their popularity in joint support formulas.viii Cat's Claw This South American rainforest herb has a history of use dating back at least 2000 years. Modern research has documented its anti-inflammatory and antioxidant properties, and preliminary research has begun to investigate its potential benefits in supporting joint comfort.ix Yucca A native of the Southwestern United States and Mexico, yucca is a source of both saponins and antioxidant polyphenols. It has a long history of traditional use for reducing joint discomfort.x Summary Quality Statement - A Higher Standard **None of the above statements have been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. i Richy F, et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med. 2003 Jul 14;163(13):1514-22. ii Natural Standard: the authority on integrative medicine [Internet]. Cambridge (MA): Natural Standard; c2007. Boswellia (Boswellia serrata Roxb.); [cited 2007 Nov 18]; Available from: http://www.naturalstandard.com/naturalstandard/monographs/monoframeset.asp?monograph=/monographs/herbssupplements/boswellia.asp&patientVersion=/monographs/herbssupplements/patient-boswellia.asp iii Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J. 2003 Nov;17(14):1975-85. iv Brien S, et al. Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257. v Natural Standard: the authority on integrative medicine [Internet]. Cambridge (MA): Natural Standard; c2007. Feverfew (Tanacetum parthenium L. Schultz-Bip.); [cited 2007 Nov 30]; Available from: http://www.naturalstandard.com/naturalstandard/monographs/monoframeset.asp?monograph=/monographs/herbssupplements/feverfew.asp&patientVersion=/monographs/herbssupplements/patient-feverfew.asp vi Efficacy of oral PerluxanT intake in subjects with knee osteoarthritis: a randomized, double?blind study. vii Natural Standard: the authority on integrative medicine [Internet]. Cambridge (MA): Natural Standard; c2007. Willow bark (Salix spp.); [cited 2007 Nov 30]; Available from: http://www.naturalstandard.com/naturalstandard/monographs/monoframeset.asp?monograph=/monographs/herbssupplements/willowbark.asp&patientVersion=/monographs/herbssupplements/patient-willowbark.asp viii Kariya Y, et al. Occurrence of chondroitin sulfate E in glycosaminoglycan isolated from the body wall of sea cucumber Stichopus japonicus. J Biol Chem. 1990 Mar 25;265(9):5081-5. ix Hardin SR. Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis. Complement Ther Clin Pract. 2007 Feb;13(1):25-8. x Cheeke PR, Anti-inflammatory and anti-arthritic effects of Yucca schidigera: a review. J Inflamm (Lond). 2006 Mar 29;3:6. |
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